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T35862 |
Cucurbit[8]uril
|
|
Others
|
|
Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, de... |
|
T21246 |
Metsulfuron-methyl
|
|
Others
|
|
Metsulfuron-methyl is a systemic selective wheat field high-efficiency sulfonylurea herbicide, which mainly controls most broadleaf weeds and grass weeds in wheat fields. |
|
T7413 |
JNJ-5207852
|
|
Histamine Receptor
|
|
JNJ-5207852 is a novel, non-imidazole histamine H3 receptor antagonist, with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor. |
|
T9193 |
ACH-000143
|
|
Melatonin Receptor
,
MT Receptor
|
|
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2. |
|
T13950 |
UC-514321
|
|
Apoptosis
,
STAT
|
|
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity. |
|
T9050 |
AG-270
|
|
Others
,
Methionine Adenosyltransferase (MAT)
|
|
AG-270 is an allosteric and orally active inhibitor of MAT2A. |
|
T8646 |
URB937
|
|
FAAH
|
|
URB937 is an inhibitor of FAAH and increases anandamide levels(IC50 : 26.8 nM). |
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T8418 |
DCLK1-IN-1
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|
Others
|
|
DCLK1-IN-1 is a selective and in vivo-compatible chemical probe of the DCLK1 kinase domain . |
|
T13974 |
ZL0580
|
|
Epigenetic Reader Domain
,
HIV Protease
|
|
ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter. |
|
T10565 |
BMS-1001 hydrochloride
|
|
PD-1/PD-L1
|
|
BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activat... |
|
T7860 |
SM-324405
|
SM 324405 |
TLR
|
|
SM-324405 is an agonist of TLR7. |
|
T9575 |
MRTX9768
|
|
Histone Methyltransferase
|
|
MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors. |
|
T4325 |
COTI-2
|
COTI 2,COTI2 |
Apoptosis
,
p53
|
|
COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity. |
|
T9812 |
Tubulin inhibitor 24
|
|
Microtubule Associated
|
|
Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization. |
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T1115 |
Doxylamine succinate
|
Decapryn |
Histamine Receptor
|
|
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and ... |
|
T8822 |
JNJ-5207852 dihydrochloride
|
|
Histamine Receptor
|
|
JNJ-5207852 dihydrochloride is a novel, non-imidazole histamine H3 receptor antagonist, with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor. |
|
T14919 |
CDKI-73
|
|
Apoptosis
,
CDK
|
|
CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effe... |
|
T2108 |
Andarine
|
S-4,GTx-007 |
Androgen Receptor
|
|
Andarine (GTx-007) (S-4) is an active partial agonist and an investigational selective androgen receptor modulator (SARM). |
|
T6446 |
Clevudine
|
L-FMAU,Levovir |
HBV
,
DNA/RNA Synthesis
|
|
Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The ... |
|
T13692 |
Ferric maltol
|
Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate |
Others
|
|
Ferric maltol (Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate) is a ferric, non-salt-based oral iron formulation demonstrating improved tolerance in patients with previous intolerance to other iron formulations. |
|
T41116 |
FV-100
|
Valnivudine HCl |
|
|
FV-100 (Valnivudine HCl) is a potent, selective and orally active anti-vaxx-zoster agent.FV-100 is the API for CF-1743.FV-100 exhibits very low toxicity in vivo.FV-100 is a potent, selective and orally active anti-vaxx-z... |
|
T0880 |
Bronopol
|
BNPK,BNPD |
Antibacterial
|
|
Bronopol (BNPD) is an antimicrobial agent with low mammalian toxicity (at in-use levels) and high activity against bacteria, especially the troublesome Gram-negative species. |
|
T3202 |
Fluensulfone
|
MCW-2 |
Parasite
|
|
Fluensulfone (MCW-2) is a new nematicide of the fluoroalkenyl thioether group that has significantly reduced environmental impact with low toxicity to non-target insects and mammals. |
|
T23478 |
Trometamol hydrochloride
|
TRIS hydrochloride |
Others
|
|
Trometamol hydrochloride (TRIS hydrochloride) (Tromethamine hydrochloride) is a biologically inert amino alcohol with low toxicity. Trometamol hydrochloride buffers carbon dioxide and acids in vitro and in vivo. Trometam... |
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T77550 |
O-Desmethyl Quinidine
|
|
Others
|
|
O-Desmethyl Quinidine is a novel quinidine analog with significant antiarrhythmic activity and low acute toxicity that may be useful in the treatment of cardiac arrhythmias. |
|
T0790 |
Carbaryl
|
1-naphthyl methylcarbamate,Sevin |
AChR
|
|
Carbaryl (1-naphthyl methylcarbamate) is a carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly l... |
|
T19914 |
Chlorothalonil
|
DAC 2787,Daconil,Daconil M |
Antifungal
|
|
Chlorothalonil (DAC 2787) is a broad-spectrum fungicide with high efficiency and low toxicity. Chlorothalonil is widely used to control various pests such as fruit trees and vegetable leaves. Chlorothalonil also has good... |
|
T78745 |
Mtb-IN-2
|
|
Antibiotic
|
|
Mtb-IN-2 is a small molecule compound of Mycobacterium tuberculosis (Mtb) with antimicrobial activity and low toxicity that interferes with methionine metabolism processes and can be used to study tuberculosis. |
|
T25672 |
Lesopitron
|
|
5-HT Receptor
|
|
Lesopitron is an anxiolytic with pre- and postsynaptic 5-HT1A agonist activity and is more effective than 5-HT1A agonists in rat social interaction and marmoset anxiety models. lesopitron counteracts benzodiazepine withd... |
|
T0992 |
Carbenoxolone disodium
|
Biogastrone,Duogastrone,Bioral |
Gap Junction Protein
|
|
Carbenoxolone disodium (Duogastrone) salt is an agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise, ... |
|
TQ0232 |
UNC0646
|
UNC 0646 |
Histone Methyltransferase
|
|
UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells ... |
|
TP1341L |
Polymyxin B nonapeptide acetate
|
Polymyxin B nonapeptide acetate(86408-36-8 free base) |
Antibacterial
,
Antibiotic
|
|
Polymyxin B nonapeptide acetate is a cationic cyclic peptide. Polyxin B nonapeptide is a derivative produced by enzymatic cleavage of polyxin B. Compared with polyxin B, polyxin B nonapeptide has low toxicity, lacks bact... |
|
T9172 |
Simufilam dihydrochloride
|
PTI-125 dihydrochloride |
Others
|
|
Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds a... |
|
T63081 |
KS106
|
|
|
|
KS106 is a potent inhibitor of ALDH, acting on ALDH1A1 (IC50: 334 nM), ALDH2 (IC50: 2137 nM) and ALDH3A1 (IC50: 360 nM). KS106 has anti-proliferative and anti-cancer effects with low toxicity. KS106 significantly increas... |
|
T77575 |
P-gb-IN-1
|
|
P-gp
|
|
P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow. P-gb-IN-1 has been shown to inhibit P-gp by hydrogen bonding with residues Asn 721 and Met 986. P-gb-IN-1 s... |
|
T9403 |
1,3,5-tris(pyridin-4-ylethynyl)benzene
|
|
Others
|
|
1,3,5-tris(pyridin-4-ylethynyl)benzene is a heterocyclic compound with a wide range of properties such as fluorescence and electrochemical activity with relatively low toxicity. It has been used as a building block for t... |
|
T26690 |
AVN-101
|
|
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
AVN-101 is a potent 5-HT7 receptor antagonist. |
|
T13821 |
Pirinixil
|
BR-931 |
Others
|
|
Pirinixil is a hypolipidemic low toxicity agent. |
|
T20831 |
Etrimfos
|
Ekamet,San197,San 197,Satisfar,San-197 |
|
|
Etrimfos is an organophosphorus insecticide with high efficiency and low toxicity. |
|
T27280 |
Eremomycin
|
A82846A,A-82846A,A 82846A |
|
|
Eremomycin, an antibiotic, can be used intramuscularly due to low toxicity. |
|
T20588 |
Tetrachlorvinphos
|
Stirofos |
|
|
Tetrachlorvinphos, an organophosphate cholinesterase inhibitor, is used as an insecticide. It has low toxicity to mammals. |
|
T20748 |
Furametpyr
|
Limber |
|
|
Furametpyr is a kind of low toxicity pesticides used to control plant diseases caused by various pathogenic microorganisms. |
|
T31064 |
CP-5484
|
CP 5484,UNII-A53TMV6VUN,CP5484 |
|
|
Cp-5484 is a new kind of Quaternary carbapenem with strong anti MRSA activity and low acute toxicity. |
|
T31528 |
Disodium sebacate
|
Sebacic Acid Disodium Salt,Decanedioic Acid Disodium Salt,Disodium Decanedioate |
|
|
Disodium sebacate is a 10-carbon-atom dicarboxylic acid, proposed as substrate for parenteral nutrition. It has low toxicity. |
|
T12824 |
S55746 hydrochloride
|
BLC201 (hydrochloride) |
BCL
|
|
S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity. |
|
T73417 |
Con B-1
|
|
|
|
ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells . |
|
T61692 |
Glyoxalase I inhibitor 6
|
|
|
|
Glyoxalase I inhibitor 6 (Compound 9j) is an inhibitor of glyoxalase I (Glo-I) with an IC50 value of 1.13 μM. This compound shows potential as an anticancer agent, demonstrating low toxicity [1]. |
|
T39682 |
Gunagratinib
|
ICP-192 |
|
|
Gunagratinib (ICP-192) is a potent and selective, orally active pan-FGFR (fibroblast growth factor receptors) inhibitor with low toxicity, exhibiting irreversible covalent binding to effectively inhibit FGFR activities. ... |
|
T63552 |
FtsZ-IN-1
|
|
|
|
FtsZ-IN-1 is a potent FtsZ inhibitor with a quinoline ring and has a strong inhibitory effect on Gram-positive bacteria (MIC: 0.5-8 μg/mL).FtsZ-IN-1 enhances FtsZ polymerization and significantly promotes cell elongation... |
|
T74979 |
HCVcc-IN-1
|
|
|
|
HCVcc-IN-1, a derivative of benzothiazole-2-thiophene S-glycoside, exhibits low toxicity and antiviral properties [1]. |
